Pesquisa sobre: MFN=57673 
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Descritor Inglês:   Anaplastic Lymphoma Kinase 
Descritor Espanhol:   Quinasa de Linfoma Anaplásico 
Descritor Português:   Quinase do Linfoma Anaplásico 
Sinônimos Inglês:   ALK Kinase
ALK Tyrosine Kinase Receptor
Anaplastic Lymphoma Receptor Tyrosine Kinase
CD246 Antigen
Nucleophosmin Anaplastic Lymphoma Kinase
Nucleophosmin-Anaplastic Lymphoma Kinase  
Categoria:   D08.811.913.696.620.682.725.400.002
Definição Inglês:   A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA. 
Nota Histórica Inglês:   2019 (1994) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AG agonists
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CH chemistry CL classification
DF deficiency DE drug effects
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PH physiology
RE radiation effects TU therapeutic use
UL ultrastructure  
Número do Registro:   57673 
Identificador Único:   D000077548 

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