Pesquisa sobre: MFN=57597 
Descritores Encontrados: 1
Mostrando: 1 .. 1  

 1 / 1 DeCS     
Descritor Inglês:   Pregnane X Receptor 
Descritor Espanhol:   Receptor X de Pregnano 
Descritor Português:   Receptor de Pregnano X 
Sinônimos Inglês:   NR1I2
Nuclear Receptor Subfamily 1, Group I, Member 2
SXR Receptor
Steroid X Receptor
Steroid and Xenobiotic Receptor  
Categoria:   D12.776.826.750.075
Definição Inglês:   Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES. 
Nota Histórica Inglês:   2019 (1998) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AG agonists
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CH chemistry CL classification
DF deficiency DE drug effects
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PH physiology
RE radiation effects TU therapeutic use
UL ultrastructure  
Número do Registro:   57597 
Identificador Único:   D000077297 

Ocorrência na BVS: