Pesquisa sobre: MFN=57527 
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Descritor Inglês:   Sorafenib 
Descritor Espanhol:   Sorafenib 
Descritor Português:   Sorafenibe 
Sinônimos Inglês:   4-(4-(3-(4-Chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxylic acid methyamide-4-methylbenzenesulfonate
BAY 43 9006
BAY 43-9006
BAY 439006
BAY 545 9085
BAY 545-9085
BAY 5459085
BAY 673472
BAY-545-9085
BAY-673472
BAY5459085
Nexavar
Sorafenib N Oxide
Sorafenib N-Oxide
Sorafenib Tosylate  
Categoria:   D02.455.426.559.389.703.757
D02.948.681.757
D03.066.515.530.750
D03.383.725.547.530.750
Definição Inglês:   A niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy. 
Ação Farmacológica:   Antineoplastic Agents
Protein Kinase Inhibitors
 
Nota Histórica Inglês:   2019 (2003) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Número do Registro:   57527 
Identificador Único:   D000077157 

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