Pesquisa sobre: MFN=57523 
Descritores Encontrados: 1
Mostrando: 1 .. 1  

 1 / 1 DeCS     
Descritor Inglês:   Progranulins 
Descritor Espanhol:   Progranulinas 
Descritor Português:   Progranulinas 
Sinônimos Inglês:   Acrogranin
Granulin Precursor
Granulin Precursor Protein
PC Cell Derived Growth Factor
PC Cell-Derived Growth Factor
Categoria:   D06.472.699.682
Definição Inglês:   Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE. 
Nota Histórica Inglês:   2019 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Número do Registro:   57523 
Identificador Único:   D000077153 

Ocorrência na BVS: