Pesquisa sobre: MFN=57503 
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Descritor Inglês:   Tuberous Sclerosis Complex 2 Protein 
Descritor Espanhol:   Proteína 2 del Complejo de la Esclerosis Tuberosa 
Descritor Português:   Proteína 2 do Complexo Esclerose Tuberosa 
Sinônimos Inglês:   Tuberin
Tuberous Sclerosis 2 Protein  
Categoria:   D12.644.360.938
Definição Inglês:   An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN (TSC1) and other signaling factors to negatively regulate MTORC1 and affect cell growth and proliferation. It can also function as GTPASE-ACTIVATING PROTEIN (GAP) for RHEB GTPASE to activate mTORC1 independent of its role in the complex. Structurally, it interacts with TSC1 through its N-terminus, which also contains a leucine zipper and coiled-coil region. It also has multiple phosphorylation sites for different cell signaling kinases, a central coiled-coil region, a C-terminal GAP domain and CALMODULIN binding domain. Mutations in the TSC2 gene are associated with TUBEROUS SCLEROSIS. 
Nota Histórica Inglês:   2019 (1994) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   57503 
Identificador Único:   D000077005 

Ocorrência na BVS: