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Descritor Inglês:   CRISPR-Associated Protein 9 
Descritor Espanhol:   Proteína 9 Asociada a CRISPR 
Descritor Português:   Proteína 9 Associada à CRISPR 
Sinônimos Inglês:   CRISPR Associated Protein 9
Cas9 Endonuclease
Cas9 Enzyme
Cas9 Protein
Endonuclease, Cas9
Enzyme, Cas9  
Categoria:   D08.811.277.352.355.325.150
Definição Inglês:   An RNA-guided endodeoxyribonuclease that associates with CRISPR SEQUENCES in STREPTOCOCCUS PYOGENES and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small GUIDE RNA (sgRNAs). Structurally, Cas9 consists of an ALPHA-HELIX module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand. Specificity for the DNA target depends on the presence of a protospacer adjacent motif (PAM) sequence, a 2-6 nucleotide DNA sequence immediately following the sequence targeted by Cas9. 
Relacionados Inglês:   CRISPR-Cas Systems
Gene Editing
Nota Histórica Inglês:   2019 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   57498 
Identificador Único:   D000076987 

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