Pesquisa sobre: MFN=57121 
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Descritor Inglês:   Forkhead Box Protein L2 
Descritor Espanhol:   Proteína Forkhead Box L2 
Descritor Português:   Proteína Forkhead Box L2 
Sinônimos Inglês:   FOXL2 Protein
Forkhead Box L2 Protein  
Categoria:   D12.776.260.950.249.032
Definição Inglês:   A forkhead box transcription factor that is expressed in the developing eyelid and during very early development of the gonad, prior to sex determination. It is essential for development of the ovary and inhibits SOX9 TRANSCRIPTION FACTOR to prevent differentiation to testes. It also induces APOPTOSIS in ovarian cells. Mutations in the FOXL2 gene are associated with BLEPHAROPHIMOSIS; Ptosis, and Epicanthus inversus (BPES with ovarian failure). 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   57121 
Identificador Único:   D000074842 

Ocorrência na BVS: