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Descritor Inglês:   Transcription Factor 4 
Descritor Espanhol:   Factor de Transcripción 4 
Descritor Português:   Fator de Transcrição 4 
Sinônimos Inglês:   TCF-4 Protein
TCF-4 Transcription Factor
TCF4 Transcription Factor
TCF 4 Protein
TCF 4 Transcription Factor
Transcription Factor, TCF-4
Transcription Factor, TCF4  
Categoria:   D12.776.
Definição Inglês:   A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder. 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   57107 
Identificador Único:   D000073940 

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