Pesquisa sobre: MFN=57096 
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Descritor Inglês:   Centromere Protein A 
Descritor Espanhol:   Proteína A Centromérica 
Descritor Português:   Proteína Centromérica A 
Sinônimos Inglês:   CENP-A Protein
CENPA Protein
Centromere Autoantigens 17K
Centromere Protein 17K
Autoantigens 17K, Centromere
CENP A Protein  
Categoria:   D12.776.157.687.173
Definição Inglês:   A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES. 
Nota Histórica Inglês:   2018 (1987) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   57096 
Identificador Único:   D000076247 

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