Pesquisa sobre: MFN=57057 
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Descritor Inglês:   DCC Receptor 
Descritor Espanhol:   Receptor DCC 
Descritor Português:   Receptor DCC 
Sinônimos Inglês:   DCC Tumor Suppressor Protein
DCC-Netrin-1 Receptor
Deleted in Colorectal Carcinoma Protein
DCC Netrin 1 Receptor
Receptor, DCC
Receptor, DCC-Netrin-1  
Categoria:   D12.644.360.075.413
Definição Inglês:   A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells. 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AG agonists
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CH chemistry CL classification
DF deficiency DE drug effects
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PH physiology
RE radiation effects TU therapeutic use
UL ultrastructure  
Número do Registro:   57057 
Identificador Único:   D000075389 

Ocorrência na BVS: