Pesquisa sobre: MFN=57053 
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Descritor Inglês:   Cytokine TWEAK 
Descritor Espanhol:   Citocina TWEAK 
Descritor Português:   Citocina TWEAK 
Sinônimos Inglês:   Apo3 Ligand
TNF-Related Weak Inducer of Apoptosis
TWEAK Cytokine
Tumor Necrosis Factor Ligand Superfamily Member 12
Cytokine, TWEAK
Ligand, Apo3
TNF Related Weak Inducer of Apoptosis
TWEAK, Cytokine  
Categoria:   D12.644.276.374.750.155
Definição Inglês:   A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION. 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   57053 
Identificador Único:   D000074049 

Ocorrência na BVS: