Pesquisa sobre: MFN=57027 
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Descritor Inglês:   Lysine Acetyltransferase 5 
Descritor Espanhol:   Lisina Acetiltransferasa 5 
Descritor Português:   Lisina Acetiltransferase 5 
Sinônimos Inglês:   HIV-1-Tat Interactive Protein Tip60
KAT5 (TIP60) Protein
HIV 1 Tat Interactive Protein Tip60  
Categoria:   D08.811.913.050.134.415.500.062
Definição Inglês:   A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN. 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   57027 
Identificador Único:   D000074443 

Ocorrência na BVS: