Pesquisa sobre: MFN=57013 
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Descritor Inglês:   Tripartite Motif-Containing Protein 28 
Descritor Espanhol:   Proteína 28 que Contiene Motivos Tripartito 
Descritor Português:   Proteína 28 com Motivo Tripartido 
Sinônimos Inglês:   TRIM28 Protein
Tripartite Motif Containing Protein 28  
Categoria:   D08.811.464.938.750.782
Definição Inglês:   A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53. 
Relacionados Inglês:   PHD Zinc Fingers
RING Finger Domains
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   57013 
Identificador Único:   D000076183 

Ocorrência na BVS: