Pesquisa sobre: MFN=57012 
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Descritor Inglês:   F-Box-WD Repeat-Containing Protein 7 
Descritor Espanhol:   Proteína 7 que Contiene Repeticiones F-Box-WD 
Descritor Português:   Proteína 7 com Repetições F-Box-WD 
Sinônimos Inglês:   F-Box and WD-40 Domain-Containing Protein 7
FBXW7 Protein
F Box WD Repeat Containing Protein 7
F Box and WD 40 Domain Containing Protein 7  
Categoria:   D08.811.464.938.750.750.750
Definição Inglês:   A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES. 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   57012 
Identificador Único:   D000073979 

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