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Descritor Inglês:   High-Temperature Requirement A Serine Peptidase 2 
Descritor Espanhol:   Serina Peptidasa A2 que Requiere Temperaturas Altas 
Descritor Português:   Serina Peptidase 2 de Requerimento de Alta Temperatura A 
Sinônimos Inglês:   HtrA Serine Peptidase 2
HtrA2 Protease
Omi Serine Protease
Serine Protease HTRA2
Serine Protease Omi
HTRA2, Serine Protease
High Temperature Requirement A Serine Peptidase 2
Omi, Serine Protease
Protease HTRA2, Serine
Protease Omi, Serine
Protease, HtrA2
Protease, Omi Serine
Serine Protease, Omi  
Categoria:   D08.811.277.656.300.760.431
Definição Inglês:   A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE. 
Relacionados Inglês:   PDZ Domains
Nota Histórica Inglês:   2018 (2000) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   57008 
Identificador Único:   D000074923 

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