Pesquisa sobre: MFN=57002 
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Descritor Inglês:   SAM Domain and HD Domain-Containing Protein 1 
Descritor Espanhol:   Proteína 1 que Contiene Dominios SAM y HD 
Descritor Português:   Proteína 1 com Domínio SAM e Domínio HD 
Sinônimos Inglês:   SAMHD1 Deoxynucleoside Triphosphate Triphosphohydrolase
SAMHD1 Protein
SAM Domain and HD Domain Containing Protein 1  
Categoria:   D08.811.277.040.725
Definição Inglês:   A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2). 
Nota Histórica Inglês:   2018 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   57002 
Identificador Único:   D000076106 

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