Pesquisa sobre: MFN=56985 
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Descritor Inglês:   Mechanistic Target of Rapamycin Complex 2 
Descritor Espanhol:   Diana Mecanicista del Complejo 2 de la Rapamicina 
Descritor Português:   Alvo Mecanístico do Complexo 2 de Rapamicina 
Sinônimos Inglês:   MTORC-2
TOR Complex 2
TORC2
Target of Rapamycin Complex 2
mTORC2
Complex 2, TOR  
Categoria:   D05.500.356
D08.811.913.696.620.682.700.931.750
D12.776.476.925.750
Definição Inglês:   A multiprotein complex consisting of MTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like MTORC1, it also regulates cell growth and proliferation in response to growth factors but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS. In contrast to MTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical role in AKT1 PROTEIN KINASE phosphorylation and activation. 
Nota Histórica Inglês:   2018 (2013) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   56985 
Identificador Único:   D000076225 

Ocorrência na BVS:
 
MEDLINE    

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