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Descritor Inglês:   Nedd4 Ubiquitin Protein Ligases 
Descritor Espanhol:   Ubiquitina-Proteína Ligasas Nedd4 
Descritor Português:   Ubiquitina-Proteína Ligases Nedd4 
Sinônimos Inglês:   Nedd4 Proteins
Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase
Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 Ligase  
Categoria:   D05.500.199.500
Definição Inglês:   E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE. 
Nota Histórica Inglês:   2018 (1996) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   56981 
Identificador Único:   D000075702 

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