Pesquisa sobre: ALARMINS 
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Descritor Inglês:   Alarmins 
Descritor Espanhol:   Alarminas 
Descritor Português:   Alarminas 
Sinônimos Inglês:   Alarmin
Alarmin Proteins
Damage-Associated Molecular Pattern Molecules
Danger-Associated Molecular Pattern Molecules
Damage Associated Molecular Pattern Molecules
Danger Associated Molecular Pattern Molecules  
Categoria:   D23.035
Definição Inglês:   A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis. 
Nota Histórica Inglês:   2016 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   55964 
Identificador Único:   D000067531 

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