Search on: MULTIPLE ENDOCRINE NEOPLASIA TYPE 2A 
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Descriptor English:   Multiple Endocrine Neoplasia Type 2a 
Descriptor Spanish:   Neoplasia Endocrina Múltiple Tipo 2a 
Descriptor Portuguese:   Neoplasia Endócrina Múltipla Tipo 2a 
Synonyms English:   MEA 2a
MEA II
MEA IIa
MEN II
MEN IIa
MEN-2A Syndrome
MEN2a
Multiple Endocrine Neoplasia Type 2
Multiple Endocrine Neoplasia, Type IIa
Multiple Endocrine Neoplasms Type 2a
Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
MEN 2A Syndrome
MEN-2A Syndromes
Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma
MEN 2
MEN 2a
Neoplasia, Multiple Endocrine Type 2a
Neoplasms, Multiple Endocrine Type 2a
Sipple Syndrome  
Tree Number:   C04.588.322.400.505
C04.651.600.505
C04.700.630.505
C16.320.700.630.505
C19.344.400.505
Definition English:   A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease. 
Indexing Annotation English:   coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent
History Note English:   95; MEA II, MEN II, & SIPPLE SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94 
Allowable Qualifiers English:  
BS blood supply BL blood
CF cerebrospinal fluid CI chemically induced
CH chemistry CL classification
CO complications CN congenital
DI diagnosis DG diagnostic imaging
DH diet therapy DT drug therapy
EC economics EM embryology
EN enzymology EP epidemiology
EH ethnology ET etiology
GE genetics HI history
IM immunology ME metabolism
MI microbiology MO mortality
NU nursing PS parasitology
PA pathology PP physiopathology
PC prevention & control PX psychology
RT radiotherapy RH rehabilitation
SC secondary SE secretion
SU surgery TH therapy
UL ultrastructure UR urine
VE veterinary VI virology
Record Number:   32133 
Unique Identifier:   D018813 

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