Search on: MULTIPLE SCLEROSIS 
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Descriptor English:   Multiple Sclerosis 
Descriptor Spanish:   Esclerosis Múltiple 
Descriptor Portuguese:   Esclerose Múltipla 
Synonyms English:   Disseminated Sclerosis
Sclerosis, Multiple
Sclerosis, Disseminated
Multiple Sclerosis, Acute Fulminating
MS (Multiple Sclerosis)  
Tree Number:   C10.114.375.500
C10.314.350.500
C20.111.258.250.500
Definition English:   An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) 
See Related English:   Myelitis, Transverse
 
Allowable Qualifiers English:  
BL blood CF cerebrospinal fluid
CI chemically induced CL classification
CO complications CN congenital
DI diagnosis DG diagnostic imaging
DH diet therapy DT drug therapy
EC economics EM embryology
EN enzymology EP epidemiology
EH ethnology ET etiology
GE genetics HI history
IM immunology ME metabolism
MI microbiology MO mortality
NU nursing PS parasitology
PA pathology PP physiopathology
PC prevention & control PX psychology
RT radiotherapy RH rehabilitation
SU surgery TH therapy
UR urine VE veterinary
VI virology  
Record Number:   9296 
Unique Identifier:   D009103 

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