Search on: MULTIPLE ENDOCRINE NEOPLASIA TYPE 1 
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Descriptor English:   Multiple Endocrine Neoplasia Type 1 
Descriptor Spanish:   Neoplasia Endocrina Múltiple Tipo 1 
Descriptor Portuguese:   Neoplasia Endócrina Múltipla Tipo 1 
Synonyms English:   Multiple Endocrine Neoplasia Type I
Multiple Endocrine Neoplasms Type 1
Neoplasia, Multiple Endocrine Type 1
Neoplasms, Multiple Endocrine Type 1
Neoplasms, Multiple Endocrine Type I
Wermer Syndrome  
Tree Number:   C04.588.322.400.500
C04.651.600.500
C04.700.630.500
C16.320.700.630.500
C19.344.400.500
Definition English:   A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13). 
Indexing Annotation English:   coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent
History Note English:   95; MEA I, MEN I, & WERMER SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94 
Allowable Qualifiers English:  
BS blood supply BL blood
CF cerebrospinal fluid CI chemically induced
CH chemistry CL classification
CO complications CN congenital
DI diagnosis DG diagnostic imaging
DH diet therapy DT drug therapy
EC economics EM embryology
EN enzymology EP epidemiology
EH ethnology ET etiology
GE genetics HI history
IM immunology ME metabolism
MI microbiology MO mortality
NU nursing PS parasitology
PA pathology PP physiopathology
PC prevention & control PX psychology
RT radiotherapy RH rehabilitation
SC secondary SU surgery
TH therapy UL ultrastructure
UR urine VE veterinary
VI virology  
Record Number:   32134 
Unique Identifier:   D018761 

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