Search on: LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL 
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Descriptor English:   Leukoencephalopathy, Progressive Multifocal 
Descriptor Spanish:   Leucoencefalopatía Multifocal Progresiva 
Descriptor Portuguese:   Leucoencefalopatia Multifocal Progressiva 
Synonyms English:   JC Polyomavirus Encephalopathy
Encephalopathies, JC Polyomavirus
Encephalopathy, JC Polyomavirus
JC Polyomavirus Encephalitis
Leukoencephalopathies, Progressive Multifocal
Multifocal Leukoencephalopathies, Progressive
Multifocal Leukoencephalopathy, Progressive
Progressive Multifocal Leukoencephalopathies
Encephalitis, JC Polyomavirus
Progressive Multifocal Leukoencephalopathy  
Tree Number:   C02.182.525.500
C02.256.721.500
C02.290.575
C02.839.550
C10.228.140.430.520.750.500
C10.228.140.695.750
C10.228.228.245.340.500
C10.228.228.399.750.500
C10.314.450
Definition English:   An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7) 
History Note English:   1973(1971) 
Allowable Qualifiers English:  
BL blood CF cerebrospinal fluid
CI chemically induced CL classification
CO complications CN congenital
DI diagnosis DG diagnostic imaging
DH diet therapy DT drug therapy
EC economics EM embryology
EN enzymology EP epidemiology
EH ethnology ET etiology
GE genetics HI history
IM immunology ME metabolism
MI microbiology MO mortality
NU nursing PS parasitology
PA pathology PP physiopathology
PC prevention & control PX psychology
RT radiotherapy RH rehabilitation
SU surgery TH therapy
TM transmission UR urine
VE veterinary VI virology
Record Number:   29437 
Unique Identifier:   D007968 

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