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Descriptor English:   Lambert-Eaton Myasthenic Syndrome 
Descriptor Spanish:   Síndrome Miasténico de Lambert-Eaton 
Descriptor Portuguese:   Síndrome Miastênica de Lambert-Eaton 
Synonyms English:   Eaton-Lambert Myasthenic Syndrome
Lambert-Eaton Syndrome
Myasthenic-Myopathic Syndrome of Eaton-Lambert
Myasthenic-Myopathic Syndrome of Lambert-Eaton
Myopathic-Myasthenic Syndrome of Eaton-Lambert
Myopathic-Myasthenic Syndrome of Lambert-Eaton
Eaton Lambert Myasthenic Syndrome
Eaton Lambert Syndrome
Eaton-Lambert Myasthenic-Myopathic Syndrome
Eaton-Lambert Myopathic-Myasthenic Syndrome
Eaton-Lambert Myopathic-Myasthenic Syndromes
Lambert Eaton Myasthenic Syndrome
Lambert Eaton Syndrome
Lambert-Eaton Myasthenic-Myopathic Syndrome
Lambert-Eaton Myasthenic-Myopathic Syndromes
Lambert-Eaton Myopathic-Myasthenic Syndrome
Lambert-Eaton Myopathic-Myasthenic Syndromes
Myasthenic Myopathic Syndrome of Eaton Lambert
Myasthenic Myopathic Syndrome of Lambert Eaton
Myasthenic Syndrome, Eaton-Lambert
Myasthenic Syndrome, Lambert Eaton
Myopathic Myasthenic Syndrome of Eaton Lambert
Syndrome, Eaton-Lambert
Syndrome, Eaton-Lambert Myasthenic
Syndrome, Lambert-Eaton
Syndrome, Lambert-Eaton Myasthenic
Eaton-Lambert Syndrome
Myasthenic Syndrome, Lambert-Eaton  
Tree Number:   C04.588.614.550.225
Definition English:   An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471) 
History Note English:   1990 
Allowable Qualifiers English:  
BL blood CF cerebrospinal fluid
CI chemically induced CL classification
CO complications CN congenital
DI diagnosis DG diagnostic imaging
DH diet therapy DT drug therapy
EC economics EM embryology
EN enzymology EP epidemiology
EH ethnology ET etiology
GE genetics HI history
IM immunology ME metabolism
MI microbiology MO mortality
NU nursing PS parasitology
PA pathology PP physiopathology
PC prevention & control PX psychology
RT radiotherapy RH rehabilitation
SU surgery TH therapy
UR urine VE veterinary
VI virology  
Record Number:   24764 
Unique Identifier:   D015624 

Occurrence in VHL: