Search on: IMMUNOGLOBULINS 
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Descriptor English:   Immunoglobulins 
Descriptor Spanish:   Inmunoglobulinas 
Descriptor Portuguese:   Imunoglobulinas 
Synonyms English:   Immunoglobulin
Globulins, Immune
Immune Globulins  
Tree Number:   D12.776.124.486.485
D12.776.124.790.651
D12.776.377.715.548
Definition English:   Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses. 
Indexing Annotation English:   general: prefer specifics; /admin: consider also IMMUNOGLOBULINS, INTRAVENOUS; /defic permitted but consider also IMMUNOLOGIC DEFICIENCY SYNDROMES ; /ther use: consider also IMMUNOGLOBULIN THERAPY see IMMUNIZATION, PASSIVE; allotypes = IMMUNOGLOBULIN ALLOTYPES or specifics
Pharmacological Action:   Immunologic Factors
 
See Related English:   Immunity
Paraproteinemias
 
History Note English:   72(70); IMMUNE SERUM GLOBULIN was heading 1965; GLOBULINS, IMMUNE & IMMUNE GLOBULINS were see IMMUNOGLOBULINS, INTRAVENOUS 1992-93 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PD pharmacology PH physiology
PO poisoning RE radiation effects
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   22210 
Unique Identifier:   D007136 

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