Search on: EXENATIDE 
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Descriptor English:   Exenatide 
Descriptor Spanish:   Exenatida 
Descriptor Portuguese:   Exenatida 
Synonyms English:   AC 2993
AC 2993 LAR
Ex4 Peptide
Exendin 4
ITCA 650
Peptide, Ex4  
Tree Number:   D12.644.187
Definition English:   A synthetic form of exendin-4, a 39-amino acid peptide isolated from the venom of the Gila monster lizard (Heloderma suspectum). Exenatide increases CYCLIC AMP levels in pancreatic acinar cells and acts as a GLUCAGON-LIKE PEPTIDE-1 RECEPTOR (GLP-1) agonist and incretin mimetic, enhancing insulin secretion in response to increased glucose levels; it also suppresses inappropriate glucagon secretion and slows gastric emptying. It is used an anti-diabetic and anti-obesity agent. 
Pharmacological Action:   Hypoglycemic Agents
Anti-Obesity Agents
History Note English:   2019 (1992) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   57573 
Unique Identifier:   D000077270 

Occurrence in VHL: