Search on: EPIDERMAL GROWTH FACTOR 
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Descriptor English:   Epidermal Growth Factor 
Descriptor Spanish:   Factor de Crecimiento Epidérmico 
Descriptor Portuguese:   Fator de Crescimento Epidérmico 
Synonyms English:   EGF
Epidermal Growth Factor-Urogastrone
Growth Factor, Epidermal
Growth Factor-Urogastrone, Epidermal
Human Urinary Gastric Inhibitor
Urogastrone
beta Urogastrone
beta-Urogastrone  
Tree Number:   D06.472.317.350
D12.644.276.382.500
D12.776.467.382.500
D23.529.382.500
Definition English:   A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form. 
See Related English:   Anti-Ulcer Agents
ErbB Receptors
Gastrointestinal Agents
 
History Note English:   2000(1982); use PEPTIDES 1977-1981; for UROGASTRONE use GASTROINTESTINAL HORMONES 1963-1981 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   4896 
Unique Identifier:   D004815 

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